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Hisao Hayashi Selected Research

Familial apoceruloplasmin deficiency

8/2018The interactions between iron and copper in genetic iron overload syndromes and primary copper toxicoses in Japan.
1/2017Coexistence of Copper in the Iron-Rich Particles of Aceruloplasminemia Brain.
6/2015Copper Accumulates in Hemosiderins in Livers of Patients with Iron Overload Syndromes.
9/2013Various copper and iron overload patterns in the livers of patients with Wilson disease and idiopathic copper toxicosis.
9/2012Clinicopathological study of Japanese patients with genetic iron overload syndromes.
11/2010Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders.
6/2009Special stain and X-ray probe microanalysis of livers with Wilson disease.
11/2006Copper- and iron-rich matrices in hepatocellular lipofuscin particles of a young male patient: diagnostic ultrastructures for Wilson disease.
9/2006Compound overload of copper and iron in patients with Wilson's disease.
11/2004[Wilson's disease and its pharmacological treatment].

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Hisao Hayashi Research Topics

Disease

24Iron Overload
03/2021 - 09/2004
19Hemochromatosis (Bronze Diabetes)
03/2021 - 06/2003
15Hepatolenticular Degeneration (Wilson's Disease)
12/2019 - 11/2004
9Chronic Hepatitis C
11/2015 - 01/2002
7Anemia
08/2020 - 11/2008
5Hyperferritinemia
03/2021 - 09/2005
5Liver Diseases (Liver Disease)
03/2017 - 09/2004
5Chronic Idiopathic Jaundice (Dubin Johnson Syndrome)
10/2007 - 01/2003
4Fibrosis (Cirrhosis)
06/2014 - 11/2004
3Liver Failure
08/2018 - 01/2010
3Hyperbilirubinemia
10/2004 - 01/2003
2type 2 Hemochromatosis
01/2020 - 03/2012
2Liver Cirrhosis (Hepatic Cirrhosis)
01/2020 - 01/2002
2Iron-Deficiency Anemia (Anemia, Iron Deficiency)
11/2015 - 02/2012
2Hepatitis
01/2010 - 08/2006
2Chronic Hepatitis (Chronic Active Hepatitis)
03/2009 - 11/2004
2Inflammation (Inflammations)
11/2008 - 01/2002
2Diabetes Mellitus
03/2005 - 06/2003
1Cardiomyopathies (Cardiomyopathy)
01/2020
1Fatigue
01/2020
1Atrophy
10/2018
1Inborn Genetic Diseases (Disease, Hereditary)
08/2018
1Nervous System Diseases (Neurological Disorders)
01/2017
1Hepatomegaly
08/2013
1Iron Deficiencies
02/2012
1Thalassemia
01/2012
1Non-alcoholic Fatty Liver Disease
01/2012
1Brain Diseases (Brain Disorder)
01/2010
1Acute Liver Failure (Fulminant Hepatic Failure)
01/2010
1Fatty Liver
06/2009
1Infections
11/2008
1Disease Progression
11/2008
1Hyperglycemia
05/2008
1Neoplasms (Cancer)
05/2008
1Massive Hepatic Necrosis
08/2006
1Jaundice (Icterus)
09/2004

Drug/Important Bio-Agent (IBA)

29IronIBA
03/2021 - 01/2002
16CopperIBA
12/2019 - 11/2004
10metal transporting protein 1 (ferroportin)IBA
03/2021 - 09/2005
10Familial apoceruloplasmin deficiencyIBA
08/2018 - 11/2004
7HepcidinsIBA
08/2018 - 11/2008
6Ferritins (Ferritin)IBA
12/2017 - 01/2010
5HemosiderinIBA
12/2017 - 02/2012
4Ceruloplasmin (Ferroxidase)IBA
08/2018 - 11/2006
4Transferrin Receptors (Transferrin Receptor)IBA
03/2017 - 06/2003
4ATP-Binding Cassette Sub-Family B Member 4IBA
04/2005 - 01/2003
3Transaminases (Aminotransferases)IBA
01/2020 - 01/2002
3Alanine Transaminase (SGPT)IBA
12/2019 - 06/2004
3Idiopathic Copper ToxicosisIBA
09/2013 - 09/2011
2Transferrin (beta 2 Transferrin)IBA
03/2021 - 09/2005
2EnzymesIBA
02/2014 - 01/2010
1copper oxidaseIBA
01/2017
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
12/2015
1DeferasiroxFDA Link
11/2011
1Biomarkers (Surrogate Marker)IBA
11/2010
1Coloring Agents (Dyes)IBA
06/2009
1Fixatives (Pickling Agents)IBA
06/2009
1Ursodeoxycholic Acid (Urso)FDA LinkGeneric
03/2009
1Ribavirin (Virazole)FDA LinkGeneric
11/2008
1Hormones (Hormone)IBA
11/2008
1Messenger RNA (mRNA)IBA
11/2008
1Phorbol EstersIBA
05/2008
1Protein Kinase CIBA
05/2008
1Transcription Factors (Transcription Factor)IBA
05/2008
1NF-kappa B (NF-kB)IBA
05/2008
1LipofuscinIBA
11/2006
1Malondialdehyde (Propanedial)IBA
08/2006
1Heme (Haem)IBA
08/2006
1Trientine (Trien)FDA Link
10/2005
1Glucose (Dextrose)FDA LinkGeneric
03/2005
1Copper-Transporting ATPasesIBA
11/2004
1BilirubinIBA
09/2004
1InterferonsIBA
09/2004

Therapy/Procedure

8Therapeutics
05/2011 - 06/2004
3Chelation Therapy (Therapy, Chelation)
03/2017 - 11/2004
2Aftercare (After-Treatment)
02/2012 - 09/2006
1Slit Lamp
06/2012
1Drug Therapy (Chemotherapy)
01/2010
1Lasers (Laser)
11/2008